Phosphorylated neurofilament heavy chain: a biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis

As potential treatments for C9ORF72-associated amyotrophic lateral sclerosis (c9ALS) approach clinical trials, the identification of prognostic biomarkers for c9ALS becomes a priority. We show that levels of phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid (CSF) predict disease...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Gendron, Tania F., Daughrity, Lillian M., Heckman, Michael G., Diehl, Nancy N., Wuu, Joanne, Miller, Timothy M., Pastor, Pau, Trojanowski, John Q., Grossman, Murray, Berry, James D., Hu, William T., Ratti, Antonia, Benatar, Michael, Silani, Vincenzo, Glass, Jonathan D., Floeter, Mary Kay, Jeromin, Andreas, Boylan, Kevin B., Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676468/
https://ncbi.nlm.nih.gov/pubmed/28628244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24980
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