Notch1 ablation radiosensitizes glioblastoma cells

Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients. Furthermore, using the CRISPR/Cas9 system,...

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Udgivet i:Oncotarget
Main Authors: Han, Na, Hu, Guangyuan, Shi, Lei, Long, Guoxian, Yang, Lin, Xi, Qingsong, Guo, Qiuyun, Wang, Jianhua, Dong, Zhen, Zhang, Mengxian
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675693/
https://ncbi.nlm.nih.gov/pubmed/29152141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21409
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