Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

As Otto Warburg first observed, cancer cells largely favor fermentative glycolysis for growth even under aerobic conditions. This energy paradox also extends to rapidly growing normal cells indicating that glycolysis is optimal for fast growth and biomass production. Here we further explored this co...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: de Padua, Monique Cunha, Delodi, Giulia, Vučetić, Milica, Durivault, Jérôme, Vial, Valérie, Bayer, Pascale, Noleto, Guilhermina Rodrigues, Mazure, Nathalie M., Ždralević, Maša, Pouysségur, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675658/
https://ncbi.nlm.nih.gov/pubmed/29152106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21007
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