Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma

To identify cellular and molecular changes that driver pediatric low grade glioma (PLGG) progression, we analyzed putative cancer stem cells (CSCs) and evaluated key biological changes in a novel and progressive patient-derived orthotopic xenograft (PDOX) mouse model. Flow cytometric analysis of 22...

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Vydáno v:Oncotarget
Hlavní autoři: Kogiso, Mari, Qi, Lin, Lindsay, Holly, Huang, Yulun, Zhao, Xiumei, Liu, Zhigang, Braun, Frank K., Du, Yuchen, Zhang, Huiyuan, Bae, Goeun, Zhao, Sibo, Injac, Sarah G., Sobieski, Mary, Brunell, David, Mehta, Vidya, Tran, Diep, Murray, Jeffrey, Baxter, Patricia A., Yuan, Xiao-Jun, Su, Jack M., Adesina, Adekunle, Perlaky, Laszlo, Chintagumpala, Murali, Parsons, D. Williams, Lau, Ching C., Stephan, Clifford C., Lu, Xinyan, Li, Xiao-Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675646/
https://ncbi.nlm.nih.gov/pubmed/29152094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20713
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