The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells

The Wilms’ tumor gene 1 (WT1) is recurrently mutated in acute myeloid leukemia. Mutations and high expression of WT1 associate with a poor prognosis. In mice, WT1 cooperates with the RUNX1/RUNX1T1 (AML1/ETO) fusion gene in the induction of acute leukemia, further emphasizing a role for WT1 in leukem...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nilsson, Helena Jernmark, Montano, Giorgia, Ullmark, Tove, Lennartsson, Andreas, Drott, Kristina, Järvstråt, Linnea, Nilsson, Björn, Vidovic, Karina, Gullberg, Urban
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675621/
https://ncbi.nlm.nih.gov/pubmed/29152069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19896
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