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Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib
Poly (ADP-ribose) polymerase inhibitors (PARPi) have been developed and tested in a context of combining it with double-stranded (ds) DNA repair defects or inhibitors, as PARP inhibitor impairs single-stranded (ss) DNA break repair, resulting in the activation of the dsDNA break repair machinery. Ra...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5675614/ https://ncbi.nlm.nih.gov/pubmed/29152062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19667 |
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