Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects

Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to cognitive deficits in both schizophrenia patients and animal models. The molecular mechanisms underlying...

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Détails bibliographiques
Publié dans:Nat Neurosci
Auteurs principaux: Ibi, Daisuke, de la Fuente Revenga, Mario, Kezunovic, Nebojsa, Muguruza, Carolina, Saunders, Justin M, Gaitonde, Supriya A, Moreno, José L, Ijaz, Maryum K, Santosh, Vishaka, Kozlenkov, Alexey, Holloway, Terrell, Seto, Jeremy, García-Bea, Aintzane, Kurita, Mitsumasa, Mosley, Grace E, Jiang, Yan, Christoffel, Daniel J, Callado, Luis F, Russo, Scott J, Dracheva, Stella, López-Giménez, Juan F, Ge, Yongchao, Escalante, Carlos R, Meana, J Javier, Akbarian, Schahram, Huntley, George W, González-Maeso, Javier
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675106/
https://ncbi.nlm.nih.gov/pubmed/28783139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4616
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