Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer

Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain containing protein 4 (BRD4) have been shown to associate with these TFs and contribute to aggressive cancers includi...

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Foilsithe in:Cell Rep
Main Authors: Urbanucci, Alfonso, Barfeld, Stefan, Kytölä, Ville, Itkonen, Harri M., Coleman, Ilsa M., Vodák, Daniel, Sjöblom, Liisa, Sheng, Xia, Tolonen, Teemu, Minner, Sarah, Burdelski, Christoph, Kivinummi, Kati K., Kohvakka, Annika, Kregel, Steven, Takhar, Mandeep, Alshalalfa, Mohammed, Davicioni, Elai, Erho, Nicholas, Lloyd, Paul, Karnes, R. Jeffrey, Ross, Ashley E., Schaeffer, Edward M., Vander Griend, Donald J., Knapp, Stefan, Corey, Eva, Feng, Felix Y., Nelson, Peter S., Saatcioglu, Fahri, Knudsen, Karen E., Tammela, Teuvo L.J., Sauter, Guido, Schlomm, Thorsten, Nykter, Matti, Visakorpi, Tapio, Mills, Ian G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675034/
https://ncbi.nlm.nih.gov/pubmed/28591577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.049
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