Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are poorly understood. In this study, we show that fibronectin (Fn) assembled by CAFs mediates CAF–cancer c...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Erdogan, Begum, Ao, Mingfang, White, Lauren M., Means, Anna L., Brewer, Bryson M., Yang, Lijie, Washington, M. Kay, Shi, Chanjuan, Franco, Omar E., Weaver, Alissa M., Hayward, Simon W., Li, Deyu, Webb, Donna J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674895/
https://ncbi.nlm.nih.gov/pubmed/29021221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201704053
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