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Simultaneous determination of acyclovir, ganciclovir, and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in human plasma using high-performance liquid chromatography

Acyclovir, ganciclovir and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine are active in vitro against the Epstein–Barr virus (EBV) but their in vivo anti-EBV activity is not well understood. We developed a novel, sensitive high-performance liquid chromatography assay with ultraviolet detection for...

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Publicat a:Biomed Chromatogr
Autors principals: Weller, Dennis R., Balfour, Henry H., Vezina, Heather E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674524/
https://ncbi.nlm.nih.gov/pubmed/19358150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.1192
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