Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses.

The activity, metabolism, and mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and varicella-zoster virus (VZV) were studied. Compared to acyclovir (ACV), H2G has superior activity against VZV (50% inhibitory conce...

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Autors principals: Lowe, D M, Alderton, W K, Ellis, M R, Parmar, V, Miller, W H, Roberts, G B, Fyfe, J A, Gaillard, R, Ertl, P, Snowden, W
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC162829/
https://ncbi.nlm.nih.gov/pubmed/7486922
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