Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses.

The activity, metabolism, and mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and varicella-zoster virus (VZV) were studied. Compared to acyclovir (ACV), H2G has superior activity against VZV (50% inhibitory conce...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Lowe, D M, Alderton, W K, Ellis, M R, Parmar, V, Miller, W H, Roberts, G B, Fyfe, J A, Gaillard, R, Ertl, P, Snowden, W
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1995
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7486922/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.8.1802
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