Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells

Targeting model antigens (Ags) to Clec9A on DC has been shown to induce, not only cytotoxic T cells, but also high levels of Ab. In fact, Ab responses against immunogenic Ag were effectively generated even in the absence of DC-activating adjuvants. Here we tested if targeting weakly immunogenic puta...

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Bibliographic Details
Published in:NPJ Vaccines
Main Authors: Park, Hae-Young, Tan, Peck S., Kavishna, Ranmali, Ker, Anna, Lu, Jinhua, Chan, Conrad E. Z., Hanson, Brendon J., MacAry, Paul A., Caminschi, Irina, Shortman, Ken, Alonso, Sylvie, Lahoud, Mireille H.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674066/
https://ncbi.nlm.nih.gov/pubmed/29263886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-017-0033-5
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