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Cytotoxicity of Aconitum alkaloid and its interaction with calf thymus DNA by multi-spectroscopic techniques

The cytotoxicities of three aconitum alkaloids- aconitine, hypaconitine and mesaconitine, and their abilities to bind DNA have been explored. Rat myocardial cells H9c2 were treated with aconitum alkaloids and assessed the cytotoxicities by using MTT assay and flow cytometry. Apoptosis was evidenced...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Fei, Tan, Xiaoxin, Han, Xu, Li, Xiang, Li, Nan, Kang, Weijun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674014/
https://ncbi.nlm.nih.gov/pubmed/29109516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15240-9
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