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Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum

Familial Alzheimer’s disease (AD) is caused by mutations in the genes that encode amyloid precursor protein (APP) and presenilins. Disturbances in calcium homeostasis have been observed in various cellular and animal models of AD and are proposed to underlie the pathogenesis of the disease. Furtherm...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Gazda, Kinga, Kuznicki, Jacek, Wegierski, Tomasz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673940/
https://ncbi.nlm.nih.gov/pubmed/29109429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15166-2
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