VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

Exacerbation of macrophage-mediated inflammation contributes to pathogenesis of various inflammatory diseases, but the immunometabolic programs underlying regulation of macrophage activation are unclear. Here we show that V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein...

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Vydáno v:Nat Commun
Hlavní autoři: Li, Jialin, Diao, Bo, Guo, Sheng, Huang, Xiaoyong, Yang, Chengying, Feng, Zeqing, Yan, Weiming, Ning, Qin, Zheng, Lixin, Chen, Yongwen, Wu, Yuzhang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673889/
https://ncbi.nlm.nih.gov/pubmed/29109438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01327-4
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