Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes

Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribut...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Björk, Susann, Ojala, Elina A., Nordström, Tommy, Ahola, Antti, Liljeström, Mikko, Hyttinen, Jari, Kankuri, Esko, Mervaala, Eero
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673656/
https://ncbi.nlm.nih.gov/pubmed/29163220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00884
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