Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system

BACKGROUND CONTEXT: Intervertebral disc (IVD) degeneration, a major cause of low back pain, is considered to be induced by daily mechanical loading. Mechanical stress is widely known to affect cell survival and extracellular matrix metabolism in many cell types. Although the involvement of integrin...

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Dades bibliogràfiques
Publicat a:Spine J
Autors principals: Kurakawa, Takuto, Kakutani, Kenichiro, Morita, Yusuke, Kato, Yuki, Yurube, Takashi, Hirata, Hiroaki, Miyazaki, Shingo, Terashima, Yoshiki, Maeno, Koichiro, Takada, Toru, Doita, Minoru, Kurosaka, Masahiro, Inoue, Nozomu, Masuda, Koichi, Nishida, Kotaro
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673479/
https://ncbi.nlm.nih.gov/pubmed/25546513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spinee.2014.12.143
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