Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system

BACKGROUND CONTEXT: Intervertebral disc (IVD) degeneration, a major cause of low back pain, is considered to be induced by daily mechanical loading. Mechanical stress is widely known to affect cell survival and extracellular matrix metabolism in many cell types. Although the involvement of integrin...

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Udgivet i:Spine J
Main Authors: Kurakawa, Takuto, Kakutani, Kenichiro, Morita, Yusuke, Kato, Yuki, Yurube, Takashi, Hirata, Hiroaki, Miyazaki, Shingo, Terashima, Yoshiki, Maeno, Koichiro, Takada, Toru, Doita, Minoru, Kurosaka, Masahiro, Inoue, Nozomu, Masuda, Koichi, Nishida, Kotaro
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673479/
https://ncbi.nlm.nih.gov/pubmed/25546513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spinee.2014.12.143
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