Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

INTRODUCTION: Nutrient deprivation is a likely contributor to intervertebral disc (IVD) degeneration. Silent mating type information regulator 2 homolog 1 (SIRT1) protects cells against limited nutrition by modulation of apoptosis and autophagy. However, little evidence exists regarding the extent t...

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Publié dans:Arthritis Res Ther
Auteurs principaux: Miyazaki, Shingo, Kakutani, Kenichiro, Yurube, Takashi, Maeno, Koichiro, Takada, Toru, Zhang, Zhongying, Kurakawa, Takuto, Terashima, Yoshiki, Ito, Masaaki, Ueha, Takeshi, Matsushita, Takehiko, Kuroda, Ryosuke, Kurosaka, Masahiro, Nishida, Kotaro
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571076/
https://ncbi.nlm.nih.gov/pubmed/26373839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0763-6
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