RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit

Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path....

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Milligan, Laura, Sayou, Camille, Tuck, Alex, Auchynnikava, Tatsiana, Reid, Jane EA, Alexander, Ross, Alves, Flavia de Lima, Allshire, Robin, Spanos, Christos, Rappsilber, Juri, Beggs, Jean D, Kudla, Grzegorz, Tollervey, David
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673307/
https://ncbi.nlm.nih.gov/pubmed/29027900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27082
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