Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These “non-metastatic” exosomes stimulate an innate imm...

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發表在:Nat Commun
Main Authors: Plebanek, Michael P., Angeloni, Nicholas L., Vinokour, Elena, Li, Jia, Henkin, Anna, Martinez-Marin, Dalia, Filleur, Stephanie, Bhowmick, Reshma, Henkin, Jack, Miller, Stephen D., Ifergan, Igal, Lee, Yesung, Osman, Iman, Thaxton, C. Shad, Volpert, Olga V.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673063/
https://ncbi.nlm.nih.gov/pubmed/29105655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01433-3
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