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Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake

Exosomes are nanoscale vesicles that mediate intercellular communication. Cellular exosome uptake mechanisms are not well defined partly due to the lack of specific inhibitors of this complex cellular process. Exosome uptake depends on cholesterol-rich membrane microdomains called lipid rafts, and c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Plebanek, Michael P., Mutharasan, R. Kannan, Volpert, Olga, Matov, Alexandre, Gatlin, Jesse C., Thaxton, C. Shad
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625174/
https://ncbi.nlm.nih.gov/pubmed/26511855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15724
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