The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance

T follicular helper (Tfh) cells are a CD4(+) T cell subset critical for long-lived humoral immunity. We hypothesized that integrins play a decisive role in Tfh cell biology. Here we show that Tfh cells expressed a highly active form of leukocyte function-associated antigen-1 (LFA-1) that was require...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Meli, Alexandre P., Fontés, Ghislaine, Avery, Danielle T., Leddon, Scott A., Tam, Mifong, Elliot, Michael, Ballesteros-Tato, Andre, Miller, Jim, Stevenson, Mary M., Fowell, Deborah J., Tangye, Stuart G., King, Irah L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672956/
https://ncbi.nlm.nih.gov/pubmed/27760339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.09.018
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