Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways

Rapidly proliferating tumors are exposed to a hypoxic microenvironment because of their density, high metabolic consumption, and interruptions in blood flow because of immature angiogenesis. Cellular responses to hypoxia promote highly malignant and metastatic behavior, as well as a chemotherapy-res...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Zhang, Kangling, Xu, Pei, Sowers, James L., Machuca, Daniel F., Mirfattah, Barsam, Herring, Jason, Tang, Hui, Chen, Yan, Tian, Bing, Brasier, Allan R., Sowers, Lawrence C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5671999/
https://ncbi.nlm.nih.gov/pubmed/28874504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000154
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