The effect of diagnostic criteria on outcome measures in preclinical and prodromal Alzheimer's disease: Implications for trial design

INTRODUCTION: We investigated the influence of different inclusion criteria for preclinical and prodromal Alzheimer's disease (AD) on changes in biomarkers and cognitive markers and on trial sample size estimates. METHODS: We selected 522 cognitively normal subjects and 872 subjects with mild c...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (N Y)
Main Authors: Bertens, Daniela, Tijms, Betty M., Vermunt, Lisa, Prins, Niels D., Scheltens, Philip, Visser, Pieter Jelle
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5671625/
https://ncbi.nlm.nih.gov/pubmed/29124109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2017.08.005
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