Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates

Despite decades of clinical trials for diffuse intrinsic pontine glioma (DIPG), patient survival does not exceed 10% at two years post-diagnosis. Lack of benefit from systemic chemotherapy may be attributed to an intact bloodbrain barrier (BBB). We aim to develop a theoretical model including releva...

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Veröffentlicht in:Front Oncol
Hauptverfasser: El-Khouly, Fatma E., van Vuurden, Dannis G., Stroink, Thom, Hulleman, Esther, Kaspers, Gertjan J. L., Hendrikse, N. Harry, Veldhuijzen van Zanten, Sophie E. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670105/
https://ncbi.nlm.nih.gov/pubmed/29164054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00254
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