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Dual inhibition of Hedgehog and c-Met pathways for pancreatic cancer treatment

Pancreatic adenocarcinoma (PDA) is one of the most chemotherapy and radiotherapy resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown previously by our group to be key regulatory pathways in the primary tumor growth and metastases formation. Targeting both the HGF/c-Met and Hh path...

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Detalles Bibliográficos
Publicado en:Mol Cancer Ther
Main Authors: Rucki, Agnieszka A., Xiao, Qian, Muth, Stephen, Chen, Jianlin, Che, Xu, Kleponis, Jennifer, Sharma, Rajni, Anders, Robert A., Jaffee, Elizabeth M., Zheng, Lei
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670001/
https://ncbi.nlm.nih.gov/pubmed/28864680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0452
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