Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer

BACKGROUND: Approximately 20-25% of ovarian cancers are attributable to germline or somatic BRCA1/2 mutations, resulting in defects in the homologous recombination pathway. Inactivation of these genes can also be mediated by epigenetic changes, e.g., hypermethylation of CpG islands in the promoter r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Prieske, Katharina, Prieske, Stefan, Joosse, Simon A., Trillsch, Fabian, Grimm, Donata, Burandt, Eike, Mahner, Sven, Schmalfeldt, Barbara, Milde-Langosch, Karin, Oliveira-Ferrer, Leticia, Woelber, Linn
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669950/
https://ncbi.nlm.nih.gov/pubmed/29137324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20945
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