Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer

BACKGROUND: Approximately 20-25% of ovarian cancers are attributable to germline or somatic BRCA1/2 mutations, resulting in defects in the homologous recombination pathway. Inactivation of these genes can also be mediated by epigenetic changes, e.g., hypermethylation of CpG islands in the promoter r...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Prieske, Katharina, Prieske, Stefan, Joosse, Simon A., Trillsch, Fabian, Grimm, Donata, Burandt, Eike, Mahner, Sven, Schmalfeldt, Barbara, Milde-Langosch, Karin, Oliveira-Ferrer, Leticia, Woelber, Linn
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669950/
https://ncbi.nlm.nih.gov/pubmed/29137324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20945
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