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Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2

Gab2 is a large disordered protein that regulates several cellular signalling pathways and is overexpressed in different forms of cancer. Because of its disordered nature, a detailed characterization of the mechanisms of recognition between Gab2 and its physiological partners is particularly difficu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Toto, Angelo, Bonetti, Daniela, De Simone, Alfonso, Gianni, Stefano
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669894/
https://ncbi.nlm.nih.gov/pubmed/29137268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19323
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