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Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy

Successful treatment of neurofibromatosis type 1 (NF1)-associated tumors poses a significant clinical challenge. While the primary underlying genetic defect driving RAS signaling is well described, recent evidence suggests immune dysfunction contributes to tumor pathogenesis and malignant transforma...

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Vydáno v:Oncotarget
Hlavní autoři: Haworth, Kellie B., Arnold, Michael A., Pierson, Christopher R., Choi, Kwangmin, Yeager, Nicholas D., Ratner, Nancy, Roberts, Ryan D., Finlay, Jonathan L., Cripe, Timothy P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669868/
https://ncbi.nlm.nih.gov/pubmed/29137242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18301
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