Knockout of Apolipoprotein E in rabbit promotes premature intervertebral disc degeneration: A new in vivo model for therapeutic approaches of spinal disc disorders

Intervertebral disc (IVD) degeneration that accelerates the loss of disc structural and functional integrities is recognized as one of the major factors of chronic back pain. Cardiovascular risk factors, such as deficits of apolipoproteins that elevate the levels of cholesterol and triglycerides, ar...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Beierfuß, Anja, Dietrich, Hermann, Kremser, Christian, Hunjadi, Monika, Ritsch, Andreas, Rülicke, Thomas, Thomé, Claudius, Mern, Demissew Shenegelegn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669473/
https://ncbi.nlm.nih.gov/pubmed/29099857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187564
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