Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

Transfection of rat skeletal muscle in vivo is a widely used research model. However, gene electrotransfer protocols have been developed for mice and yield variable results in rats. We investigated whether changes in hyaluronidase pre-treatment and plasmid DNA delivery can improve transfection effic...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Akerstrom, Thorbjorn, Vedel, Kenneth, Needham, Josefine, Hojman, Pernille, Kontou, Eftychia, Hellsten, Ylva, Wojtaszewski, Jørgen F.P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669402/
https://ncbi.nlm.nih.gov/pubmed/29124223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.10.007
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