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Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change

Mapping cis-acting expression quantitative trait loci (cis-eQTL) has become a popular approach for characterizing proximal genetic regulatory variants. In this paper, we describe and characterize log allelic fold change (aFC), the magnitude of expression change associated with a given genetic varian...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Mohammadi, Pejman, Castel, Stephane E., Brown, Andrew A., Lappalainen, Tuuli
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668944/
https://ncbi.nlm.nih.gov/pubmed/29021289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.216747.116
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