Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes

Genome-wide association studies (GWAS) have identified multiple, shared allelic associations with many autoimmune diseases. However, the pathogenic contributions of variants residing in risk loci remain unresolved. The location of the majority of shared disease-associated variants in noncoding regio...

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Udgivet i:Genome Res
Main Authors: Newman, Jeremy R.B., Conesa, Ana, Mika, Matthew, New, Felicia N., Onengut-Gumuscu, Suna, Atkinson, Mark A., Rich, Stephen S., McIntyre, Lauren M., Concannon, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668939/
https://ncbi.nlm.nih.gov/pubmed/29025893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.217984.116
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