Application of termite hindgut metagenome derived carboxyl ester hydrolases in the modification of cephalosporin substrates

In the pharmaceutical industry, de-acetylated cephalosporins are highly valuable starting materials for producing semi-synthetic β-lactam antibiotics. In this study a fosmid metagenome library from termite hindgut symbionts was screened for carboxyl ester hydrolases capable of de-acetylating cephalo...

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Bibliographic Details
Published in:Biochem Biophys Rep
Main Authors: Mokoena, Nobalanda, Mathiba, Kgama, Tsekoa, Tsepo, Steenkamp, Paul, Rashamuse, Konanani
Format: Artigo
Language:Inglês
Published: Elsevier 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668906/
https://ncbi.nlm.nih.gov/pubmed/29124186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.08.016
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