Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment

Mitochondria in cardiac myocytes are critical for generating ATP to meet the high metabolic demands associated with sarcomere shortening. Distinct remodeling of mitochondrial structure and function occur in cardiac myocytes in both developmental and pathological settings. However, the factors that u...

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Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Lyra-Leite, Davi M., Andres, Allen M., Petersen, Andrew P., Ariyasinghe, Nethika R., Cho, Nathan, Lee, Jezell A., Gottlieb, Roberta A., McCain, Megan L.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668604/
https://ncbi.nlm.nih.gov/pubmed/28733449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00290.2017
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