Modulation of telomere protection by the PI3K/AKT pathway

Telomeres and the insulin/PI3K pathway are considered hallmarks of aging and cancer. Here, we describe a role for PI3K/AKT in the regulation of TRF1, an essential component of the shelterin complex. PI3K and AKT chemical inhibitors reduce TRF1 telomeric foci and lead to increased telomeric DNA damag...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Méndez-Pertuz, Marinela, Martínez, Paula, Blanco-Aparicio, Carmen, Gómez-Casero, Elena, Belen García, Ana, Martínez-Torrecuadrada, Jorge, Palafox, Marta, Cortés, Javier, Serra, Violeta, Pastor, Joaquin, Blasco, Maria A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668434/
https://ncbi.nlm.nih.gov/pubmed/29097657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01329-2
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