Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

T-cell infiltration into tumors represents a critical bottleneck for immune-mediated control of cancer. We previously showed that this bottleneck can be overcome by depleting immunosuppressive Foxp3(+) regulatory T cells (Tregs), a process which can increase frequencies of tumor-infiltrating lymphoc...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Colbeck, Emily J., Jones, Emma, Hindley, James P., Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F., Ager, Ann, Gallimore, Awen
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668144/
https://ncbi.nlm.nih.gov/pubmed/28947544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0131
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