A phase I clinical trial of binimetinib in combination with FOLFOX in patients with advanced metastatic colorectal cancer who failed prior standard therapy

BACKGROUND: This was a first in-human, open-label, dose-escalation phase I study conducted to evaluate the maximum tolerated dose (MTD), safety, and efficacy of the combination of oral binimetinib and FOLFOX. MATERIALS AND METHODS: Patients with metastatic colorectal cancer (mCRC) who progressed on...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Cho, May, Gong, Jun, Frankel, Paul, Synold, Timothy W., Lim, Dean, Chung, Vincent, Chao, Joseph, Li, Daneng, Chen, Yuan, Sentovich, Stephen, Melstrom, Kurt, Singh, Gagandeep, Luevanos, Eloise, Fakih, Marwan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Clinical Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668088/
https://ncbi.nlm.nih.gov/pubmed/29108355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19336
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