STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines

Pancreatic ductal adenocarcinomas (PDACs) are highly aggressive malignancies, associated with poor clinical prognosis and limited therapeutic options. Oncogenic KRAS mutations are found in over 90% of PDACs, playing a central role in tumor progression. Global gene expression profiling of PDAC reveal...

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Udgivet i:Oncotarget
Main Authors: Grant, Trevor J., Mehta, Anita K., Gupta, Anamika, Sharif, Ahmad A.D., Arora, Kshitij S., Deshpande, Vikram, Ting, David T., Bardeesy, Nabeel, Ganem, Neil J., Hergovich, Alexander, Singh, Anurag
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667982/
https://ncbi.nlm.nih.gov/pubmed/29108249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20833
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