Metapristone (RU486 metabolite) suppresses NSCLC by targeting EGFR-mediated PI3K/AKT pathway

Therapies targeting epidermal growth factor receptor (EGFR) can effectively treat with non-small cell lung cancer (NSCLC), but NSCLC’s drug resistance makes it intractable. Herein, we showed that RU486 metabolite metapristone inhibited the proliferation of various NSCLC cell lines with either wild (...

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Foilsithe in:Oncotarget
Main Authors: Shao, Jingwei, Zheng, Guirong, Chen, Hongning, Liu, Jian, Xu, Aixiao, Chen, Fan, Li, Tao, Lu, Yusheng, Xu, Jianguo, Zheng, Ning, Jia, Lee
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2017
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667967/
https://ncbi.nlm.nih.gov/pubmed/29108234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18640
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