Metapristone (RU486 metabolite) suppresses NSCLC by targeting EGFR-mediated PI3K/AKT pathway

Therapies targeting epidermal growth factor receptor (EGFR) can effectively treat with non-small cell lung cancer (NSCLC), but NSCLC’s drug resistance makes it intractable. Herein, we showed that RU486 metabolite metapristone inhibited the proliferation of various NSCLC cell lines with either wild (...

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Udgivet i:Oncotarget
Main Authors: Shao, Jingwei, Zheng, Guirong, Chen, Hongning, Liu, Jian, Xu, Aixiao, Chen, Fan, Li, Tao, Lu, Yusheng, Xu, Jianguo, Zheng, Ning, Jia, Lee
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667967/
https://ncbi.nlm.nih.gov/pubmed/29108234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18640
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