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Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity

Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to specific NRTIs has predominantly been assigned to mito...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Smith, Reuben L., Tan, Josephine M. E., Jonker, Martijs J., Jongejan, Aldo, Buissink, Thomas, Veldhuijzen, Steve, van Kampen, Antoine H. C., Brul, Stanley, van der Spek, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667870/
https://ncbi.nlm.nih.gov/pubmed/29095935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187424
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