Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

Src-family kinases (SFKs) play important roles in human biology and are key drug targets as well. However, achieving selective inhibition of individual Src-family kinases is challenging due to the high similarity within the protein family. We describe rhodium(ii) conjugates that deliver both potent...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Vohidov, Farrukh, Knudsen, Sarah E., Leonard, Paul G., Ohata, Jun, Wheadon, Michael J., Popp, Brian V., Ladbury, John E., Ball, Zachary T.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2015
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667506/
https://ncbi.nlm.nih.gov/pubmed/29142714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01602a
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