Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord

BACKGROUND: Morphine tolerance is a clinical challenge, and its pathogenesis is closely related to the neuroinflammation mediated by Toll-like receptor 4 (TLR4). In Chinese pain clinic, lidocaine is combined with morphine to treat chronic pain. We found that lidocaine sufficiently inhibited neuroinf...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Zhang, Yan, Tao, Gao-Jian, Hu, Liang, Qu, Jie, Han, Yuan, Zhang, Guangqin, Qian, Yanning, Jiang, Chun-Yi, Liu, Wen-Tao
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667445/
https://ncbi.nlm.nih.gov/pubmed/29096659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0983-6
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