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Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16(Ink4a)‐pRb and Arf‐p53 pathways
The main regulators of replicative senescence in mice are p16(Ink4a) and Arf, inhibitors of cell cycle progression. Jun dimerization protein 2 (JDP2)‐deficient mouse embryonic fibroblasts are resistant to replicative senescence through recruitment of the Polycomb repressive complexes 1 and 2 to the...
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| Pubblicato in: | FEBS Open Bio |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5666393/ https://ncbi.nlm.nih.gov/pubmed/29123987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12325 |
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