ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass

Chemotherapy promotes the development of cachexia, a debilitating condition characterized by muscle and fat loss. ACVR2B/Fc, an inhibitor of the Activin Receptor 2B signaling, has been shown to preserve muscle mass and prolong survival in tumor hosts, and to increase bone mass in models of osteogene...

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Publicat a:Sci Rep
Autors principals: Barreto, Rafael, Kitase, Yukiko, Matsumoto, Tsutomu, Pin, Fabrizio, Colston, Kyra C., Couch, Katherine E., O’Connell, Thomas M., Couch, Marion E., Bonewald, Lynda F., Bonetto, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665981/
https://ncbi.nlm.nih.gov/pubmed/29089584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15040-1
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