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Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair

Mechanical stress is one of the major aetiological factors underlying soft-tissue remodelling, especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress states lead to deviations from cellular homeostasis, resulting in subsequent cellular activation and extracellul...

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Bibliografske podrobnosti
izdano v:J R Soc Interface
Main Authors: Ayoub, Salma, Lee, Chung-Hao, Driesbaugh, Kathryn H., Anselmo, Wanda, Hughes, Connor T., Ferrari, Giovanni, Gorman, Robert C., Gorman, Joseph H., Sacks, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665836/
https://ncbi.nlm.nih.gov/pubmed/29046338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2017.0580
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