Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling

In the Drosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-κB homolog Relish and robust antimicrobial peptide gene expression. PGRP-LC, PGRP-...

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Bibliographic Details
Published in:Immunity
Main Authors: Kleino, Anni, Ramia, Nancy F., Bozkurt, Gunes, Shen, Yanfang, Nailwal, Himani, Huang, Jing, Napetschnig, Johanna, Gangloff, Monique, Chan, Francis Ka-Ming, Wu, Hao, Li, Jixi, Silverman, Neal
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665175/
https://ncbi.nlm.nih.gov/pubmed/29045898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.09.011
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