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Mevalonate metabolism governs cancer immune surveillance

The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs cellular function and survival, whereas hyperactivit...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Gruenbacher, Georg, Thurnher, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665080/
https://ncbi.nlm.nih.gov/pubmed/29123952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1342917
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